Ctgf lpa
WebApr 1, 2024 · Effect of lysophosphatidic acid (LPA) on fibrotic growth factor expression in the small airway epithelial basal cells (SAE BC). Primary SAE BC from each of 3 non-smoking individuals were plated in triplicate in the presence or absence of 1.0 μg/ml LPA and evaluated for expression of connective tissue growth factor (CTGF), endothelin-1 … WebDec 6, 2007 · Connective tissue growth factor (CTGF) seems to be involved in the fibrotic response. Several muscular dystrophies are characterized by a progressive weakness and wasting of the musculature, and by extensive fibrosis. However, the exact role of CTGF in skeletal muscle is unknown. ... (TGF-β) and lysophosphatidic acid (LPA). CTGF induced ...
Ctgf lpa
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WebSep 2, 2012 · Apical secretion of CTGF upon stimulation with LPA. Primary tubular cells were isolated from healthy parts of human kidney nephrectomies. Cells obtained from … WebApr 1, 2024 · Effect of lysophosphatidic acid (LPA) on fibrotic growth factor expression in the small airway epithelial basal cells (SAE BC). Primary SAE BC from each of 3 non …
WebJun 28, 2006 · The effect of cucurbitacin I on the expression of CTGF was investigated in a mouse renal fibroblast cell line. In a previous study we have shown that LPA-induced CTGF expression in a RhoA-dependent manner in these cells .Fibroblasts were preincubated with cucurbitacin I at concentrations, 1–10 μM, which have previously been reported to inhibit … WebSep 17, 2024 · Lysophosphatidic acid (LPA) is a small phospholipid present in many mammalian cells and tissues [].Lysophosphatidic acid affects cell migration, survival, …
WebMar 1, 2024 · CTGF expression is principally regulated at the levels of transcription, and its promoter contains a number of binding-sites for transcription factors such as Smads. 15 We recently demonstrated that LPA-induced CTGF expression by mesothelial cells is dependent on LPA 1-MRTF-SRF pathway, and that pharmacological inhibition of the … WebNational Center for Biotechnology Information
WebDec 1, 2000 · Expression of connective tissue growth factor (CTGF) was induced in renal mesangial cells by activation of heptahelical receptors by serotonin (5-HT) and lysophosphatidic acid (LPA). Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h, whereas induction of CTGF by transforming growth factor beta …
WebIf you have any further questions visit our Contact Us tab. Open Office hours will be on Friday, May 27, from 12-1 PM. Join the Conversation! If you are a CT farmer of any size … shared characteristic谬误WebAug 1, 2024 · Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell … pool safety act qldWebJan 7, 2016 · Lysophosphatidic acid (LPA) is an efficient, bioactive phospholipid involved in various biological processes. In this study, LPA-induced connective tissue growth factor (CTGF/CCN2) expression … pool safety alarm for sliding doorWeb5 . refers to populations sharing a particular characteristic, as well as geographic communities, that have been . systematically denied a full opportunity to participate in … shared characteristics crosswordWebJun 1, 2011 · The effect of LPA on the secretion of CTGF and PGF 2α from endometrial tissue was altered depending on different stages of endometrosis ( P < 0.05). ... Connective tissue growth factor (CTGF/CCN2 ... shared channel with external usersWebMar 27, 2015 · A CArG box-like element is also enclosed in the promoter of connective tissue growth factor (CTGF, CCN2) . ... MKL1 is involved in SRE and CTGF regulation in LPA-stimulated HKC-8 cells. (A) HKC-8 cells were treated with siRNA directed against MKL1 or scrambled siRNA and then transfected with an SRE construct the following day. … shared character biologyWebApr 14, 2024 · 目前包括自泌素抑制剂ziritaxestat和自泌素LPA受体1拮抗剂BMS-986020。 4. 结缔组织生长因子（CTGF）抗体. 血清中的CTGF水平与肺纤维化的严重程度相关，成纤维细胞及其前体细胞是CTGF的靶标，也可以自分泌这种促纤维化因子，故阻断CTGF的生物学活性可能会有效抗肺 ... poolsafe pool covers