Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain alleles of … See more The amino acid sequence of the transcribed FTO protein shows high similarity with the enzyme AlkB which oxidatively demethylates DNA. FTO is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylase See more The FTO gene is widely expressed in both fetal and adult tissues. See more Model organisms have been used in the study of FTO function. In contrast to the findings in humans deletion, analysis of the Fto gene in mice showed loss of function is … See more By exon trapping, Peters et al. (1999) cloned a novel gene from a region of several hundred kb deleted by the mouse 'fused toes' (FT) … See more FTO has been demonstrated to efficiently demethylate the related modified ribonucleotide, N6,2'-O-dimethyladenosine, and to an equal or lesser extent, m A, … See more Obesity 38,759 Europeans were studied for variants of FTO obesity risk allele. In particular, carriers of one copy of the allele weighed on average 1.2 kilograms (2.6 lb) more than people with no copies. Carriers of two copies (16% … See more • FTO protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Catharine Paddock (2007-04-13). "Obesity Gene Discovered". Medical News Today. Retrieved 2008-03-22. See more Webthe FTO genotype on weight loss. 21oreover, an analy M - sis of data from the Diabetes Prevention Programme (DPP) (n=1824) and the Action for Health in Diabetes study …
FTO Polymorphisms are Associated with Metabolic Dysfunction …
WebAug 26, 2024 · The FTO gene was genotyped for rs9939609 polymorphism. The association between dietary macronutrients and the FTO genotype were assessed using linear … WebApr 23, 2011 · FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life … solis key life insurance
Fat and carbohydrate intake modify the association between …
WebAmong them, FTO gene rs1477196 AA genotype was significantly related to decreased breast cancer risk compared to GG genotype, while rs16953002 AA genotype contributed to a higher breast cancer risk compared to GG genotype. Iles et al 27 found that variants of FTO gene outside of intron 1 were associated with melanoma risk. WebJan 16, 2014 · The FTO gene is expressed in the human brain, and there is evidence of association between its risk allele and reduced cerebrocortical insulin sensitivity ( 19 ). Previous studies have suggested a functional role for insulin in the regulation of energy homeostasis and body weight in the central nervous system ( 20 ). WebFeb 17, 2016 · Background: Studies have suggested that the fat mass and obesity–associated (FTO) genotype is associated with individual variability in weight … solis kaffeemühle scala zero static typ 1661