WebMar 21, 2024 · CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Glanzmann Thrombasthenia 1 . Among its related pathways are Innate Immune System and Integrin Pathway . Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity . WebApr 12, 2024 · A set of four (S100A8/A9, TSP1, FINC, IFNL1), and two sets of three proteins (S100A8/A9, TSP1, ERBB2 and S100A8/A9, TSP1, IFNL1) were selected using machine learning as multimarker panels with ...
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WebAnother discovery is that CD47 inhibits tumor angiogenesis and regulates long-term vascular responses in tumors by mediating the production of thrombospondin 1 (TSP1). 13 A mouse experiment suggested that the blockade of CD47 signaling can delay tumor growth and that CD47 may be a target for immunotherapy in human acute myeloid leukemia. 14 … WebFeb 20, 2024 · The overexpression of TSP1-CD47 signaling in diabetes is associated with endothelial cell dysfunction, which leads to impaired angiogenesis . In the ischemic retina, glia-derived TSP-1 may inhibit angiogenic responses , and deficiency of TSP-1 contributes to enhanced neovascularization in the eye (104–108). shopkins cricut cartridge
CD47结构、功能、生物大分子药物开发_肿瘤 - 搜狐
http://eowimg.alc.co.jp/np-tsp142675 WebCD47广泛的表达于细胞的表面,可与信号调节蛋白α(Signal regulatory proteinα,SIRPα)、血小板反应蛋白(thrombospondin‑1,TSP1)以及整合素(integrins)相互作用,介导凋亡、增殖、免疫等一系列的反应(Maes T,Joos GF,Brusselle GG.Am J Respir Cell Mol Biol.2012;47(3):261‑270)。 WebThe TSP1 interaction with CD47 is not well-defined but depends on a heparansulfate proteoglycan modification (HSPG; green) at CD47 Ser64 (magenta) and can be … shopkins cross stitch pattern